Total Synthesis of (−)-Enigmazole A

نویسندگان

  • Yanran Ai
  • Mariya V. Kozytska
  • Yike Zou
  • Anton S. Khartulyari
  • Amos B. Smith
چکیده

A highly convergent, stereocontrolled total synthesis of the architecturally complex marine sponge metabolite (-)-enigmazole A has been achieved. Highlights include an unprecedented late-stage large-fragment Petasis-Ferrier union/rearrangement, a multicomponent Type I Anion Relay Chemistry (ARC) tactic, and a dithiane-epoxide union in conjunction with an oxazole-directed stereoselective reduction.

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عنوان ژورنال:

دوره 137  شماره 

صفحات  -

تاریخ انتشار 2015